Podeti Koteshwar Rao
Aspergillus fumigates is an oomycyte fungi most frequently recognized as a causative agents of epizootic ulcerative syndrome (EUS) it is a seasonal and epidemic pathogens of great important in cultured fishes in both freshwater and estuarine environments. EUS is a complex infectious etiology which leads to necrosis ulcerative lesions and granulomatous response in freshwater fishes of Channa striatus. This is the cause of death of approximately 92 species that has been recorded in wild as well as in commercial culture systems worldwide. Different environmental and biological factors are responsible for the growth and establishment of A. fumigatus, which is further, attracts secondary pathogens to enter the lesions thus, increasing the severity of the fungal infection. The proper methods for identification of A. fumigatus, includes PCR detection and light microscopy. In order to discover new effective treatment to control the disease, a better understanding of the infection process is necessary. The studies on fungal infection in freshwater fish of Channa striatus indicate the immune response pattern in fish against the A. fumigatus that serves as an important key for the development of targeted therapeutics and vaccines to prevent the disease and to maintain EUS free aquaculture systems. The immune mechanisms that respond to stimulation, interaction between the immune system of host species and A. fumigatus, different factors of A. fumigatus and its pathological conditions as well as various approaches of treatment has been discussed.
KeywordsAspergillus fumigatus; EUS; PCR; Granulomatous
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