Marzieh Jamalidoust, Maryam Eskandari, Mazyar Ziyaeyan
Hepatitis C virus (HCV) is the one of the major infections transmitted through the bloodstream. Thalassemia and hemophilia patients because of regular blood transfusions are more prone to HCV infection. This study conducts to determine the prevalence of HCV, HCV viral load, genotype pattern and risk factors in thalassemia and hemophilia patients in Iran.
Among 4916 suspected HCV infection patients, referred to Prof. Alborzi Clinical Microbiology Research Center, Shiraz, Iran, from 2004 to 2019, the HCV seroprevalence rate and the HCV RNA load and genotypes was determined by the enzyme-linked immunosorbent assay and one-step Taq Man real-time PCR.
Among 4916 patients were assessed for the study, 440 were with thalassemia and 162 with hemophilia. The prevalence of HCV-Ab positivity among thalassemia and hemophilia patients was 58.9% and 87%, respectively. The most prevalent genotype was Gt-1, which was detected in 56.81% of the patients whose genotypes were assessed. The HCV viral load was generally higher among HCV seropositive patients compared to HCV seronegative patients.
Prevalence of hepatitis C among hemophilia and thalassemia patients was high. Since in these high-risk groups didn’t find any independent risk factor for HCV, it can be concluded that multi-transfusion is the only predictor for hepatitis C.
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